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Consumers increasingly learn about experimental therapies through podcasts and social media long before those therapies appear in clinical practice

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This shows that the effects induced by the intervention could either be due to the direct effects of the polyphenols or indirectly by modifying the configuration of the gut microbiota

359,360 Notably, COTI-2 not only preferentially affects tumor cells expressing mutant p53 but also affects tumor cells with wild-type p53