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Innovations in pharmaceutical formulations have substantially improved therapeutic peptide administration by providing the following advantages: long-acting delivery, precise dose administration, retention of biological activity, and improvement of patient compliance

Rapizzi et al., 2002

doi: 10.1007/s00401-011-0820-4 56 BendszusMUrbachHWolfHKSchrammJSolymosiL

However, most peptides do not penetrate skin sufficiently to achieve systemic levels