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Lower DSIP levels have been correlated with depressive states, suggesting its involvement in hypothalamic-pituitary-adrenal (HPA) axis modulation ( 11 )

In diet-induced obesity animal models, NNMT inhibition demonstrated metabolic changes including alterations in adipocyte lipid content without affecting food intake patterns, coupled with significant reductions in white adipose tissue mass in treated mice

PMID: Summary Keywords bone metabolism, gut microbiota, gut-bone axis, immune regulation, osteoporosis, probiotics, SCFAs Citation Gong Y, Ma X, Wang L, Zhang P, Liu T, Li Y and Dong W (2026) Gut microbiota orchestrates bone homeostasis: a multi-pathway network from intestine to skeleton

Hormonal Side Effects: Disruption of natural hormone production can lead to a host of endocrine issues

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