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In the Phase II obesity clinical trial MOMENTUM-1, a 2.4 mg dose of pemvidutide resulted in an average weight loss of 15.6% after 48 weeks, with the placebo-corrected figure being 13.4%

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!Safety note The FDA has reviewed reports of suicidal thoughts or actions with GLP-1 receptor agonists and, in 2026, requested removal of suicidal ideation and behavior warning language from affected GLP-1 labels after finding no increased risk

They reach that output by different routes, and that difference is the entire rationale for combining them

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