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Key Outcomes: Up to 24.2% total body weight reduction in high-dose groups

SDF-1 is thus discussed in the literature as important mediator of cardioprotective effects addressed to the use of DPP4 inhibitors (further discussed in DPP4 Substrates: SDF-1- and BNP-Dependent Effects of DPP4 Inhibitors)

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Schoenen, J

Survodutide is a concrete bet on that principle, and the reason it is studied so intensively is that the bet is testable: if the glucagon axis truly adds something, it should show up as extra weight loss, extra liver-fat reduction, and a distinct safety signature relative to GLP-1 alone