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For nausea, a significant main effect of time was observed ( 2 (3) = 14.79, p = 0.002, f = 0.54

GraphPad Prism 8.0.2 and two-tailed unpaired students t test were applied

Common Side Effects and Safety Considerations The most frequently reported side effects are gastrointestinal particularly nausea and are generally mild to moderate, most prominent during dose escalation, and tend to diminish over time

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