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PMID: 29133617

It's about receptor availability

"Zepbound slows gastric emptying and alters gut hormone signaling, which can change how food moves through the intestines," says Supriya Rao, MD , a quadruple board-certified provider in internal medicine, gastroenterology, obesity, and lifestyle medicine

[Yerba mate] could be worth trying as part of a balanced diet and healthy lifestyle, but it's important not to rely solely on it for significant weight loss, Simpson says