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Tirzepatide, the first approved dual GIP/GLP-1 receptor agonist, is a 39-amino acid peptide with an approximately 120-hour half-life supporting once-weekly dosing
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That means your body does not use insulin effectively, which can lead to fat storage and blood sugar swings
animal studies show risks
But controlled human efficacy data is sparse, and the single Phase 2 trial tested oral administration rather than the subcutaneous injection most users employ today
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