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In male reproductive pathology, ROS generated by mitochondria in asthenozoospermic sperm cause nuclear DNA strand breaks [358] and compromise chromatin condensation integrity through aberrant histone methylation patterns, which directly correlates with diminished sperm quality [351]

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[19] This conversion is catalyzed by glutathione reductase: NADPH + GSSG + H 2 O 2 GSH + NADP + + OH Roles [edit] Antioxidant [edit] GSH protects cells by quenching (reducing) reactive oxygen species

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