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The identified mechanisms include: Competitive Reuptake Inhibition: Amphetamine enters the presynaptic neuron either by passive diffusion or by acting as a competitive substrate for the plasma membrane monoamine transporters

10.1210/er.2018-00134 191 SongL.WangL.HouY.ZhouJ.ChenC.YeX.et al (2022)

Syst Rev 10:89

Gradual titration helps minimize these effects

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Taking into consideration that the structure of any organ closely reflects the state of its function