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Instead of targeting a single receptor, retatrutide activates three hormone receptors involved in appetite and metabolism: GLP-1 receptor GIP receptor Glucagon receptor Because it activates all three pathways, it is often called a triple agonist

Let the water trickle down the glass and onto the lyophilized cake

Increased Energy Expenditure: Activation of the glucagon receptor encourages the body to break down stored fat and increases the metabolic rate, further supporting weight loss

Appears to have a strong effect on body weight in many patients

More than a decade later, Novo Nordisk pioneered the creation of a new GLP-1 RA, semaglutide