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Moore LD, Le T, Fan G

Starting with a lower dose and gradually increasing it can help minimize these issues

This effect may be related to the activation of AMP-activated protein kinase (AMPK) and sirtuin1 (SIRT1)/forkhead box O1 (FOXO1) pathway (Li et al., 2018

Rhee SG, Yang KS, Kang SW, Woo HA, Chang TS

Most physicians recommend introducing one compound before the other rather than starting both simultaneously

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