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78 mTORC1 participates in protein, glucose and lipid metabolism mainly through phosphorylation and activation of p70S6 kinase 1 (S6K1), while mTORC2, an effector of PI3K, contributes to the activation of Akt

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Studies often focus on receptor-mediated signaling dynamics and their potential association with cellular metabolic regulation, protein turnover processes, and neuroendocrine feedback mechanisms, as described in cell-based and animal research literature

doi: 10.1007/s10637-018-0574-0 64 CookSISellinJH