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Lancet 392(10157):15191529

Macrolactamization is a widely utilized strategy to build a bridge due to several key advantages, including its mild reaction conditions, which are compatible with sensitive functional groups, high chemoselectivity for desired cyclic structures, and versatility stemming from the broad availability of starting materials such as amines and carbonyl-containing compounds

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Chronic inflammation and persistently elevated glucose levels are common threads in cardiovascular disease, cognitive decline, and certain cancers