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Pro-inflammatory macrophages sustain pyruvate oxidation through pyruvate dehydrogenase for the synthesis of itaconate and to enable cytokine expression

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Its feasible to consider that the [opposite] could actually happen with a therapy that delivers the antigen in the appropriate fashion to tolerogenic cell populations

It has been safely done and should open doors for other diseases like sickle cell." People with beta-thalassaemia - the most severe type of the condition - have inherited a faulty gene that affects the amount of haemoglobin produced in the body, making them very anaemic, tired and short of breath