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4a, compared with OA group, the body weight of rats in OA + saline had no significant change at 0 day ( P = 0.9993), 7th day ( P = 0.8538), 14th day ( P = 0.5209), 21st day ( P = 0.3575) and 28th day ( P = 0.8092) after treatment with saline, which indicated that saline could not induce weight loss

18 Similar height responses were shown in 2 randomized trials of rhIGF-1 therapy among patients with growth retardation (although not necessarily with confirmed SPIGFD) 25 , 26 and a case-based study of 2 prepubertal siblings with PAPP-A2 homozygous frameshift gene mutation (an autosomal recessive syndrome consisting of short stature, among other symptoms)

This transparent pricing eliminates dose-ladder surprises and makes budgeting predictable for long-term therapy

Pricing remains flat regardless of dosage tier

& Yang, Q.-W

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