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Under stimuli, CCL11 can be transported from blood to the brain across the blood-brain barrier (BBB) or be primarily secreted by activated astrocytes

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GLP-1R is expressed in bone marrow stem cells (BMSCs) [63], osteoblasts, osteocytes [64] and osteoclasts [46], which suggests that it could play a role in both bone tissue destruction and renewal

Some patients find taking their pill at a different time of day from their semaglutide dose helps reduce overlap, though timing alone isn't a reliable safety measure

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