Beyond the two primary proteins of focus in ADRD progression, glymphatic clearance also helps support removal of inflammatory markers to maintain the parenchymal environment and reduce neurotoxic load on neurons (Mogensen et al., 2021)
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In particular, GLP-1 and PYY, which are produced by enteroendocrine L cells, not only regulate the circadian rhythms of bone resorption and formation but also influence processes such as insulin secretion, appetite, and energy metabolism, which indirectly contribute to bone health
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Existing reviews tend to fall into two categories: overly broad analyses that emphasize reactive oxygen species (ROS) biology without sufficiently addressing GSH, or highly focused discussions on chemical linkers that overlook translational relevance