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Flower, G., Fritz, H., Balneaves, L.G., Verma, S., Skidmore, B., Fernandes, R., Kennedy, D., Cooley, K., Wong, R., Sagar, S

Anyone whose BMI sits below the threshold, or who doesnt have the qualifying conditions, would be unlikely to receive retatrutide on the NHS in the early years of any rollout, even after approval

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Finally, the expression of a truncated variant of SSTR5 (SST5TMD4) that shows a preferential intracellular localization but is able to mediate signal transduction (46) has been found to correlate with a reduced ability of octreotide at normalizing hormone secretion in poorly responsive tumors in vivo (47) and with aggressive features, including SS-resistance and tumor invasiveness (48, 49)