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All of these studies are hypothesis-generating and await confirmation in RCTs. According to Lane, the rationale for GLP-1 receptor agonists in lupus stems from the drugs demonstrating anti-inflammatory properties, potentially by inhibiting the NF-B pathway, which plays a crucial role in inflammation

J Neurol Neurosurg Psychiatry 96: 870883

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It also enhances insulin sensitivity and regulates blood sugar levels, leading to improved metabolic health and weight control

Like with all medications it is possible that a very small number of patients may experience very severe side effects