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In conditions like Alzheimers disease and Parkinsons disease, ongoing damage signals keep microglia stuck in a state of chronic overactivation, pushing them toward a pro-inflammatory phenotype and making them release a lot of inflammatory factors

Glutamate helps suppress neuronal activity and increases calming alpha waves, making falling asleep easier

[DOI] [PubMed] [Google Scholar] 12.Brubaker PL

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The macule is harmless, but it may be visually distracting, especially when it sits in the center of the lower lip where it is highly visible

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